From Orlando

From FL-408 W take the Florida's Turnpike exit toward Ocala. Keep Left to stay on Florida's Turnpike for 41.2 miles. Take exit 307 toward Inverness. Turn left on to FL-44 W for 15 miles. Turn right onto US-41 N which becomes Main St. Continue on FL-44 for 7.5 miles. Keep right to stay on FL-44 for 7.4 miles. Turn right on to N Turkey Oak Dr for 0.2 miles. Crystal River KOA will be on your left. 

From Tampa

From I-275 N take exit 53 to merge onto I-75 N toward Ocala for about 55 miles. Take exit 329 for FL-44 toward Inverness. Turn left onto FL-44 W and take to N Turkey Oak Dr and turn right. Crystal River KOA will be on your left.

OR

From I-275 S take exit 39 to merge onto FL-60 W. Continue onto FL-589 N for 67.1 miles. Turn left onto FL-44 W for 4.7 miles. Turn right on to N Turkey Oak Dr for 0.2 miles. Crystal River KOA will be on your left.

From Gainesville

From I-75 S take exit 350 toward Dunnellon. Merge onto FL-200 for 16.1 miles. Take a slight right onto County Rd 491 for 10.2 miles. Turn right onto County Rd 486/ W Norvell Bryant Hwy for 3.9 miles. Turn right onto FL-44 for 1.5 miles. Turn right on to N Turkey Oak Dr for 0.2 miles. Crystal River KOA will be on your left.